Heterozygosity increases microsatellite mutation rate
نویسندگان
چکیده
منابع مشابه
Mutation rate of a microsatellite sequence in normal human fibroblasts.
Dinucleotide repeats, because of their repetitive nature, are prone to frameshift mutations, most likely via a DNA-polymerase slippage mechanism. Mutation rates in microsatellite DNA sequences are high in mismatch repair-defective cells. In normal cells, only estimates of maximal rates of mutation in microsatellites have been possible previously, because of the low sensitivity of screening assa...
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IN a recent issue of Genetics, RoyChoudhury and Stephens (2007) showcased a new method for estimating the population scaled mutation rate u from microsatellite data; u is equivalent to four times the effective population size times the mutation rate per generation and can also be viewed as the scaled population size. Their approximation delivered impressively accurate results with little bias. ...
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Simple sequence repeats (SSRs, also known as microsatellites) are known to be mutational hotspots in genomes. DNA rearrangements have also been reported to accompany allopolyploidization. A study of the effect of allopolyploidization on SSR mutation is therefore important for understanding the origin and evolutionary dynamics of SSRs in allopolyploids. Three synthesized double haploid (SynDH) p...
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Microsatellites are important tools for plant breeding, genetics, and evolution, but few studies have analyzed their mutation pattern in plants. In this study, we estimated the mutation rate for 142 microsatellite loci in maize (Zea mays subsp. mays) in two different experiments of mutation accumulation. The mutation rate per generation was estimated to be 7.7 x 10(-4) for microsatellites with ...
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The evolution of higher dispersal during range expansion increases invasion speed, provided that a species can adapt sufficiently fast to novel local conditions. Iterated founder effects during range expansion, however, cause low levels of local genetic diversity at these range margins. Mutation rates can evolve, too, and using an individual-based model we show that natural selection may lead t...
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ژورنال
عنوان ژورنال: Biology Letters
سال: 2016
ISSN: 1744-9561,1744-957X
DOI: 10.1098/rsbl.2015.0929